Green’s Dictionary of Slang

little casino n.

[SE casino, a card game in which the ten of diamonds, called great casino, counts two points, and the two of spades, called little casino, counts one; note big casino n.]
(US)

1. any insignificant event or object.

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[US]B. Fisher A. Mutt in Blackbeard Compilation (1977) 34: An outrage that would have made the Portuguese assassinations look like little casino.

2. a term of familiarity, aimed at a woman.

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[US]B. Fisher A. Mutt in Blackbeard Compilation (1977) 131: [man to passing woman] Howdy, little casino. Lonesome?

3. an insignificant person.

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[US]‘O. Henry’ Works 10: We march between little casino and the North Grand Custodian of the Royal Hall Bedchamber [HDAS].
[US]McCulloch Woods Words 107: Little casino — a. A hanger-on. b. A small-bore helper.

4. gonorrhoea [compares gonorrhoea with syphilis, which would be a ‘greater’ form of VD].

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[US] (ref. to mid-19C) N. Kimball Amer. Madam (1981) 36: The two women infected a lot of the farm boys and hired hands with Little Casino (clap) and Big Casino (syphilis).
[US]S. Longstreet Wilder Shore 216: Seldom, before the age of penicillin, was a sailor [...] left uninfected by Big Casino or Little Casino, the major and minor diseases of Venus.
P. Platt Pretty Baby [film script] Are you afraid you’ll catch little casino?...The clap? [HDAS].