Green’s Dictionary of Slang

1. to render incompetent, to knock out lit. or fig.

1989

Hackworth & Sherman About Face (1991) 163: Luckily, the 190-proof had not zeroed me out completely.

2. (US/W.I.) to kill, to murder; of an object, to destroy.

1960		(con. WWII) G. Sire Deathmakers 131: The road is zeroed in with heavy mortar at twenty-foot intervals.
1976		J. Stanley World War III (1979) 41: They’ve got this entire field zeroed in.
1990		S. Morgan Homeboy 118: You didnt know she watched you zero Gloria Monday.
2000		Observer Rev. 2 Apr. 1: Iced – Caribbean criminal slang for whacked, wetjobbed, zeroed.