Green’s Dictionary of Slang

moccasined adj.

(US) drunk.

1872		Schele De Vere Americanisms 35: In the South, a man made drunk by bad liquor is said to have been ‘bitten by the snake,’ or simply to be ‘mocassined’.
1877		Bartlett Dict. Americanisms (4th edn) 398: Moccasoned [sic] Intoxicated. South Carolina.