Green’s Dictionary of Slang

1. drunk or under the influence of a drug; also fig.

1989		P. Munro Sl. U.
2015		P. Beatty Sellout (2016) 121: Tweaked on sunrise and the English Beat, cleansing their systems and their acne.

2. (also tweaked out) experiencing the effects of methamphetamine or crack cocaine.

1985		L.A. Times 4 June (San Diego Co.) V6/1: Other kids seem to look up to me because I make crystal meth and have been successful at it. ... Mentally, I’m just about tweaked to the max all the time.
1989		Seattle Times 9 July B2: A drug lab used to manufacture methamphetamines was discovered early yesterday morning after a 47-year-old Tacoma man, whom police described as ‘tweaked out,’ was arrested nude near his home.
1995		J. Stahl Permanent Midnight 319: Why don’t you let me cop you some rock [...] Get you tweaked and squeaked.
2000		P. Beatty Tuff 18: The fifth anniversary of his sister’s death, he experimented with crack and spent four days in his bedroom tweaked out of his mind.
2006		Guardian 5 June 🌐 I think it’s more than possible that these guys were totally tweaked out on speed or something when they shot those civilians.
2013		J. Stahl Bad Sex on Speed 28: That tweaked-out voice low as the hell pit he was describing.
2019		S.M. Jones Lives Laid Away [ebook] ‘Is it me or is that guy tweaked like nobody’s business?’.

3. mad.

1989

P. Munro Sl. U.

4. (also tweaked out) broken, out of order, messy.

1989		P. Munro Sl. U.
1992		D. Burke Street Talk 2 2: I dunno what his deal is but he dresses like a dode and his hair is always majorly tweaked out.

5. exhausted.

1989

P. Munro Sl. U.

6. on edge, tense, nervous, upset.

1989		P. Munro Sl. U.
1992		D. Burke Street Talk 2 52: Don’t get all tweaked.
2001		J. Stahl Plainclothes Naked (2002) 3: Bed stuff gets me tweaked on account of my childhood abuse.
2021		J. Ellroy Widespread Panic 132: I’ve scurvily skimmed your diaries — and I’m tweaked.