Green’s Dictionary of Slang

highly intoxicated on alcohol or a given drug; thus ossification n.

1900		Sun (NY) 21 May 6/4: One might say, for instance, he is ossified [...] has a shine on, has a skinful.
1901		Manchester Courier 6 July 12/1: An American paper gives a list of 200 ways of describing when a man is intoxicated. [...] he is ossified.
1902		Ade ‘R-E-M-O-R-S-E’ in Verses and Jingles (1911) 2: I was pickled, primed, and ossified.
1912		Pittsburgh Press (PA) 16 Aug. 21/5: He hopped into a booze garage [...] and proceeded to get ossified.
1922		S. Lewis Babbitt (1974) 265: Wasn’t T.D. stewed! Say, he was ossified!
1936		Archie Seale Man About Harlem 22 Aug. [synd. col.] Antics of the ossified gal on St Nicholas avenue [...] while her friends looked on.
1944		Honolulu Advertiser (HI) 19 June 5/1: President Roosevelt never commanded anyone to come to Washington and get ossified!
1958		(con. 1950) E. Frankel Band of Brothers 282: I am not tight or plastered, polluted, greased, blind, sozzled, ossified or atomized.
1971		R.D. Pharr S.R.O. (1998) 300: ‘She probably doesn’t have the slightest notion of what is going on’ [...] ‘You mean she’s ossified?’.
1975		J. Ryan Remembering How We Stood 139: If we could have delayed this ossification to the ‘Circe’ episode it would have been more in accordance with the structure of Ulysses.
1988		Sun. Tribune Colour TV & Radio 21 Feb. 12/2: Steve goes off and gets ossified in the local swillery.
1998		J. O’Connor Salesman 92: Fuckin’ bladdered he was, ossified.
2000		P. Howard Miseducation of Ross O’Carroll-Kelly (2004) 181: She’s ossified and her breath tastes of vom.
2021		L. McInerney Rules of Revelation 51: ‘You’re ossified,’ she said. ‘I’m not ossified.’ ‘He’s ossified,’ Natalie said.