Green’s Dictionary of Slang

(US) ill-health caused by lack of sexual activity.

1947		‘Imaginary Diseases’ in AS XXII:4 Apr. 305/1: lackanookie or lackanookemia. This is usually called Hawaiian Lackanookemia or ‘that old Hawaiian disease.’ It means, of course, lack o’ nookie. Lackanookie is accented on the first syllable.
1952		(con. 1920s) ‘Harry Grey’ Hoods (1953) 108: You look like you’re suffering from that rare Hawaiian disease [...] Lack, a nooky.
1972		B. Rodgers Queens’ Vernacular 155: Hawaiian disease also lakanuki, ie ‘Lack of nooky,’ no women aboard ship.
1975		I. Faust A Star in the Family 43: ‘If they ship you to Hawaii,’ he said, ‘watch out for that rare native disease.’ ‘Which one?’ ‘Lackanooky. So long, kid.’.
1989		H. Rawson Dict. of Invective (1991) 272: It has been reported that military personnel stationed in Hawaii during World War II suffered grievously from lackanookie, also called lackanookemia.
1989		R. Kantner Hell’s Only Half Full 31: ‘Lackanooky,’ Randy answered, grinning as he clanked out the door.
2000		C. Hastings Fubar 239: Between the scorching-hot weather, and my hapless condition of prolonged lackanooky, and the girls scanty little costumes and succulent tanned bodies [etc.].