Green’s Dictionary of Slang

(US drugs) to inject a drug intravenously; thus as adj. meaning intravenous.

1997		L. Pettiway Workin’ It 72: When I left home I was just using acid and IV-crank.
2001		J. Stahl Plainclothes Naked (2002) 84: The sudden [sugar] overload made her feel anxious and giddy at the same time, as if she’d IVd bad speed.