Green’s Dictionary of Slang

frisky adj.

ill-tempered, charged with aggression.

1900		‘Doss Chiderdoss’ ‘A Courting Case in Court’ Sporting Times 7 Apr. 1/4: As for Jim, he’s no brute, but he’s frisky.
1909		(ref. to 1880) J. Ware Passing Eng. of the Victorian Era.
1972		D. Jenkins Semi-Tough 190: It would be about eleven-fifteen when we got there [i.e. a stadium], he said, and that would give us plenty of time. ‘To get frisky for them piss ants,’ he said.

SE in slang uses

In compounds

frisky powder (n.) [its effects]

(drugs) cocaine.

1955		H. Braddy ‘Narcotic Argot Along the Mexican Border’ in AS XXX:2 87: FRISKY POWDER, n.phr. Cocaine.
1980		‘Gloss. of Drug Terms’ National Instit. Drug Abuse.
2001		ONDCP Street Terms 9: Friskie powder — Cocaine.