Green’s Dictionary of Slang

(Scot.) venereal disease.

1608		Pennyless Parliament of Thread-bare Poets 38: [to avoid syphilis] Drink every Morning a Draught of Noli me tangere, and, by that Means, thou shalt be sure to escape the Physician’s Purgatory.
1626		H. Cockeram Eng. Dict. Pt 1 (2nd edn) n.p.: Noli-me-tangere, The French disease.
1641		T. Vicary The English-mans treasure 112: Take Mole warpes and make them in a powder with Brimstone, and take the Iuyce of Selondine, and so let them stand certaine dayes, & after lay it in a Stillatorie [...] this water helpeth the sicknesse called Noli me tangere.
1648		T. Brugis Marrow of Physicke 17: Flos Vnguentorum [...] is good for a Canker, or Noli me tangere, it is good for Seareclothes for the Gout, Sciatica, and other Aches, and for pestilent Botches.
1676		Coles Eng. Dict. (1732).
1688		R. Holme Academy of Armory II 17 430: The Yard is [...] subject to be eaten with the Noli me tangere, or French-pox.
1728		J. Dalton Narrative of Street-Robberies 56: The Poet came in for an After-Share in the imaginary Pleasure, and might get the Noli me tangere into the Bargain.
1755		Bailey Universal Etym. Eng. Dict.
1864, 1867, 1870		Hotten Sl. Dict.
1873		Sl. Dict.
1895		C. Crowe Aus. Sl. Dict. 53: Noli-me-Tangere, a contagious disease.