Green’s Dictionary of Slang

(US) a nuisance, an annoyance.

1967

H. Ellison Would You Do It for a Penny? in Shatterday (1982) 79: A stalking ground without prey. A shandah. A pure pain in the ass. He wasted half an hour buying a can of Pledge [...] But as ye cruise, so shall ye be cruised: he was accosted briefly and toothily by an aging homosexual.