Green’s Dictionary of Slang

motherfuck v.

also motha fuck
[backform. f. motherfucker n.]

1. (orig. US) a general curse, usu. in imper., e.g., motherfuck the pigs!

[US]B. Jackson Get Your Ass in the Water (1974) 209: Motherfuck the sonofabitch that caused to call him king.
[US]M. Agar Ripping and Running 144: br.: You didn’t see that shotgun sittin the corner though did ya? bb.: Motherfuck that.
[US]E. Torres Q&A 8: Motha fuck you, ain’t tellin you shit.
[US]C. Stella Eddie’s World 74: Damn! [...] Mother fuck me!
[US]2Pac ‘Soldier Like Me’ 🎵 Motherfuck the police as we creep, in our Jeeps / Layin so long you think I’m asleep.

2. to call someone ‘motherfucker’.

[US]S. Blass Pirate for Life 111: He mother-fucked me for three days after that [i.e. a practical joke].