Green’s Dictionary of Slang

queen bee n.

[play on SE]

1. [1950s–70s] in gay uses [queen n. (2a) + SE bee but ? abbr. bitch)].

(a) a woman who likes to surround herself with young men, who may or may not be homosexual.

(b) as sense 1a but of a man, usu. homosexual himself.

2. [2000s] (US black) the woman with the largest breasts in a group.