Green’s Dictionary of Slang

(drugs) Rohypnol, a strong sedative; often in pl; also as v. to spike someone’s drink with Rohypnol.

1989		M. Muller Growing Up Drug Free 37: Smack, horse, mud, [...] roofies, the forget pill.
1999		T. Dorsey Florida Roadkill 78: She and Coleman each dropped a Roofie.
2000		‘An English Schoolgirl’ 🌐 By this time the powdered ‘rufy’ had begun to take effect. Tina had become flushed and bright-eyed and little things seemed to look quite queer.
2000		P. Beatty Tuff 164: I still got these date-rape pills from my baseball days. Roofies.
2001		ONDCP Street Terms 18: Rophies [...] Rophy [...] Ruffies [...] Ruffles — Rohypnol. [Ibid.] 22: Wolfies — Rohypnol.
2005		Mad mag. Dec. 10: Don’t think I haven’t seen you trying to slip roofies into my potions.
2009		J. Stahl Pain Killers 224: Tina opened her fist on a handful of white pills. ‘Rufies’.
2012		J. Fagan Panopticon (2013) 290: ‘What did you give her?’ ‘Everything; smack, roofies’.
2016		Huffington Post 10 Mar. 🌐 Thinking about my kids as teenagers [...] wondering if they are OK or if they have been roofied and are lying in a ditch.
2024		Bluesky 25 July 🌐 [Vance] absolutely had to roofie the couch first.