Green’s Dictionary of Slang

roofie n.2

also rophy, ruffie, ruffle, rufy, wolfie
[the drug, which causes users to appear drunk, is allegedly popular as a new form of knockout drop, prob. used to facilitate a number of rapes]

(drugs) Rohypnol, a strong sedative; often in pl; also as v. to spike someone’s drink with Rohypnol.

[US]M. Muller Growing Up Drug Free 37: Smack, horse, mud, [...] roofies, the forget pill.
[US]T. Dorsey Florida Roadkill 78: She and Coleman each dropped a Roofie.
‘An English Schoolgirl’ [Internet] By this time the powdered ‘rufy’ had begun to take effect. Tina had become flushed and bright-eyed and little things seemed to look quite queer.
[US]P. Beatty Tuff 164: I still got these date-rape pills from my baseball days. Roofies.
[US]ONDCP Street Terms 18: Rophies [...] Rophy [...] Ruffies [...] Ruffles — Rohypnol. [Ibid.] 22: Wolfies — Rohypnol.
[US]Mad mag. Dec. 10: Don’t think I haven’t seen you trying to slip roofies into my potions.
[US]J. Stahl Pain Killers 224: Tina opened her fist on a handful of white pills. ‘Rufies’.
[UK]J. Fagan Panopticon (2013) 290: ‘What did you give her?’ ‘Everything; smack, roofies’.
Huffington Post 10 Mar. [Internet] Thinking about my kids as teenagers [...] wondering if they are OK or if they have been roofied and are lying in a ditch.