Green’s Dictionary of Slang

(US) to destroy or overwhelm; usu. as adj. exflunctified, overwhelmed, destroyed.

1833		J.K. Paulding ‘Nimrod’s Wildfire Tall Talk’ n.p.: ‘Mister,’ says he, ‘I’m the best man-if I ain’t, I wish I may be tetotaciously exflunctified! I can whip my weight in wildcats and ride straight through a crabapple orchard on a flash of lightning-clear meat-axe disposition!’.
1837		R.M. Bird Nick of the Woods III 32: You switches gentlemen, do you, you exflunctified, perditioned rascal? Ar’n’t you got it, you nigger-in-law to old Sattan?
1866		Letters by an Odd Boy 165: Uncle Sam [U. S.] has sent us several cargoes of slang terms more or less familiar: a ‘splendiferous slantindicular rumbustious,’ dialect calculated to ‘raise the dander,’ ‘put in an awful fix,’ ‘catawampously exflunctify,’ cause to ‘cave in,’ ‘absquatulate,’ and ‘slope,’ the ‘stranger’ to whom it may be addressed.
1977		R. Coover Public Burning (1979) 116: Those squonks can haul off and (puff!) exfluncticate [...] the whole durn shootin’ match.