Green’s Dictionary of Slang

scuzz v.

[scuzz n. (2)]

1. to make filthy, to make a mess of.

[UK]N. Barlay Curvy Lovebox 91: Tryin’ not to scuzz his shoes in the filth.

2. in fig. use, to act in a sordid manner.

[US]H. Rawson Dict. of Invective (1991) 345: The proper adjective is scuzzy and the verb is to scuzz (someone) out.
[UK]N. Barlay Curvy Lovebox 108: Scuzzin’ round town with Nood far’s I can remember.

In phrases

scuzzed out (adj.)

(US teen) disgusted, nauseated.

W. Safire ‘On Lang.’ N.Y. Times 26 Oct. at WordSpy.com 🌐 Although ‘grossed out’ was big last year, it is already on the wane: The new form is ‘scuzzed out.’ The ‘scuz’ (rhymes with ‘fuzz’) might come from ‘disgusted’; really with-it slanguists are scuzzed out at the squared-out weirdos who still use ‘grossed out’.
C. Barry ‘Rev. of Bury Me An Angel’ SkyHighPictureShow 🌐 It starts off promising enough – director Barbara Peeters (‘Humanoids From the Deep’, 1980), brings us into a garage where a bunch of scuzzed out hippies are smokin’ weed, drinkin’ Coors, poppin’ poppers and snortin’ piles of blow off the pointed end of a Bowie knife.
scuzzed up (adj.)

deliberately filthy.

[UK]Guardian Rev. 29 Oct. 16: It has brought us the first words of wisdom from a whole host of scuzzed-up rock ’n’ roll rebels.