1. [late 19C+] a young woman [note synon. use in Kendall, Flowers of Epigrammes (1577): ‘Which are three ills that mischief men [...] The fem, the flud, the fire’].
2. [1930s+] (also femmie) an effeminate homosexual man.
3. [1940s+] a feminine lesbian.
4. [1960s+] the ‘female’ partner of a couple whether hetero- or homosexual.
[1900s] (US campus) a female-only college.