Green’s Dictionary of Slang

(US campus) to start on a trip, to go somewhere.

1973		Eble Campus Sl. Nov. 3: matriculate [...] Shall we matriculate campuswards? (Based on the conversational style of the comic strip Pogo).
1996		Eble Sl. and Sociability 42: They also enjoy creating mock learned words that sound like polysyllabic borrowings from Greek or Latin: [...] matriculate ‘start a trip’.