Green’s Dictionary of Slang

housewife n.

[metonymy, but note poss. play on 18C housewife, a small (pocket-sized) case for needles, thread, scissors etc.]

the female genitals.

[UK]Farmer & Henley Sl. and Its Analogues.
[UK]Farmer Vocabula Amatoria (1966) 240: Sanctuare, f. the female pudendum; ‘the housewife’.

SE in slang uses

In compounds

housewife’s hour (n.) [play on radio scheduling jargon]

(US gay) the afternoon, esp. as used for masturbation since nothing else is happening.

[US]B. Rodgers Queens’ Vernacular.