Green’s Dictionary of Slang

(US) exceedingly stupid.

1953		F. Paley Rumble on the Docks (1955) 159: ‘Jimmy! You no take the stuff?’ Jimmy shook his head. ‘I ain’t that jerked up!’.
1962		S. Longstreet Flesh Peddlers (1964) 17: Some jerked-up news programs and some late-hour nudniks interviewing the squares.