Green’s Dictionary of Slang

skunk n.

1. (US, also skunkie) a bedwetter; also attrib.

[US]N. Algren Walk on the Wild Side 72: I had to sleep in the Skunk Room. That’s the dorm with rubber mattresses for bed-wetters. [Ibid.] 73: I found a friend. A skunkie just like me.

2. a woman, esp. one who smells badly.

[US]E. O’Brien One Way Ticket 91: Fightin’ over a skunk with a dose of clap. Knockin’ a guy’s teeth out for makin’ a pass at a whore.
[US]M. Braly On the Yard (2002) 286: A skunk would have to be deaf, dumb, blind, and not smell none too good either before she’d put out to you.
[US]Current Sl. IV:1 14: Skunk, n. An ugly girl.
[US]E. Folb Runnin’ Down Some Lines 144: Skunk, skank, and bait refer to a female who smells badly.

3. (US) a black and white police car.

[US]L. Dills CB Slanguage.

4. in drug uses.

(a) (drugs, also skunkweed) an exceptionally strong variety of marijuana (often grown in the user’s home) with up to 30% tetrahydrocannabidinol (THC) content, thus intensifying the effects from the merely stimulating to those of such hallucinogens as LSD; thus superskunk, an even stronger variety.

[US] cited in Spears Sl. and Jargon of Drugs and Drink (1986).
[UK]Guardian 7 Apr. 9/1: Prices an ounce for British-grown [...] range from £80 to £140-£150 for skunkweed.
[UK]I. Welsh Filth 168: Skinning up a large reefer of skunk.
[UK]M. Manning Get Your Cock Out 138: They’d [...] smoked a shit load of skunk to get them mellow.
[UK](con. 1990s) N. ‘Razor’ Smith A Few Kind Words and a Loaded Gun 438: He was more a drug-man and knew everything about the cultivation of skunk-weed.
[UK]Observer Mag. 13 June 51: Skunk is today used to mean any strong weed.
[US]UGK ‘Gravy’ [lyrics] We gon’ blow a lot of skunk and we gon’ make a lot of bread.
Kool Keith ‘Track Runner’ [lyrics] Smoke kush skunk, chase it down, gin & tonic.
[UK]J. Fagan Panopticon (2013) 106: Run up the stairs, grab a pre-rolled skunk cone. It’s fucking lethal shit.

(b) (US black) poor quality marijuana.

[US]Ebonics Primer at [Internet] skunk Definition: cheap-ass, stinky weed, or marijuana for all you squares Example: Yo, this might be some skunk, but I’m still toe the fuck up.

(c) heroin.

[US]ONDCP Street Terms 19: Skunk — [...] heroin.