Green’s Dictionary of Slang

weeds, the n.

[its position on the edge of town]

1. (US tramp) a hobo camp.

[US]Monteleone Criminal Sl. (rev. edn).
[US] (ref. to c.1930s) R.A. Bruns Knights of the Road 204: Weeds. Jungle.

2. (US Und.) the outskirts, the suburbs.

[US]‘Blackie’ Audett Rap Sheet 115: Then we would pick up the tail of one of them until they got way out in the weeds at the edge of town somewheres.

In phrases

in the weeds (adj.) [golfing imagery, the weeds make the ball less accessible than on the smooth fairway]

(US) in trouble, difficulties; busy.

Story 3-5 22: In the restaurant business , that was a way of saying you were behind schedule , sweaty , too busy to think straight . It was the first expression he had learned [...] ‘ In the weeds’ .
Customer Relationship Management 1-3 32: In the restaurant biz , we would say, ‘He’s in the weeds,’ or ‘He’s snowed under,’ meaning that someone was hopelessly in over his head.
Feminist frontiers 255: If I'm really busy, if I'm in the weeds, and they want to touch me, I'll get mad. I'll tell them to stop.
[US]L. Berney Whiplash River [ebook] ‘I’m in the weeds this morning’.