shakes, the n.
1. [mid-19C+] (also shivery shakes) delirium tremens, the shaking associated with an alcoholic who has been deprived of sufficient drink to achieve normality.
2. fever, e.g. malaria.
3. [1910s+] (also shakeroos) extreme terror, nervousness.
4. [1930s+] as sense 1 in the context of withdrawal from narcotics.
5. [1940s] a similar effect to sense 1, caused by excess coffee.
6. [1940s] palsy.
7. [1950s+] great excitement.
8. an addiction to (dice) gambling.