Green’s Dictionary of Slang

exhausted, overcome.

1836–7		Dickens Pickwick Papers (1999) 523: He’s in a horrid state o’ love; reg’larly comfoozled, and done over with it.
1860		London Standard 26 May 4/6: Sur, there is a thing that has rather bothered me and my old woman lately [...] it has so comfoozled us we can maje nothing of it.
1911		H.C. Hansborough Second Amendment 53: The kid says that Miss Enid is just plumb comfoozled, whatever that is.