Green’s Dictionary of Slang

(drugs) to inject a drug.

1938		D. Castle Do Your Own Time 200: Y’ gotta lay off the wimmin, an’ don’t hype y’rself up till y’ goes out t’ heist a joint [OED].
1959		L. Lipton Holy Barbarians 83: Trying to do himself in, lushing, hyping, insane fucking, no sleep.
1971		Tidyman & Black Shaft [film script] A lot o’ hyped up black people gave you that money you’re spendin’, pimp.
1978		W.J. Buchanan Shining Season 121: ‘I’ve got to be fully responsive to them, not hyped up.’ He shook his head. ‘No shots, for now ’.