Green’s Dictionary of Slang

(orig. US) enraged.

1977		S. Berkoff East in Decadence and Other Plays (1985) 59: A victim of nuclear aggro.
1992		K. Lette Llama Parlour 177: Stefan went nuclear ’cause the photos are too soft.
2011		Observer Mag. 30 1 May. 28/2: Colleagues say he can ‘go nuclear’ when things do not turn out as planned.