Green’s Dictionary of Slang

powder n.1

1. [1910s–60s] (US) a drink of liquor, thus powdered up, drunk [joc. use of SE powder, a medicine or a dose of medicine].

2. [1920s+] (drugs) any form of powdered drug, e.g. heroin, cocaine, amphetamine.

In compounds

powder factory (n.)

[1970s] a wholesale distribution centre for narcotics.

powder puff (n.)

see separate entry.

powder works (n.)

[1910s] (US) a bar, a tavern.

In phrases

powder one’s nose (v.)

see separate entry.

powder up (v.)

[1930s–60s] (US) to drink alcohol; to become drunk.