Green’s Dictionary of Slang

home run n.

[baseball imagery]

1. an escape from prison.

[US]‘Sleepy Burke’ Prison Gates Ajar 9: I [...] jumped the fence and made a ‘home run’.

2. (US, also homer) sexual intercourse; both heterosexual and homosexual (cf. first base n. (1); second base under second adj.; third base under third adj.).

B. Blechman War of Camp Omongo 58: I hear she’s been knocked for a homer just about every year since Omongo was erected.
[US]J. Lahr Hot to Trot 16: Home run (with protection) [...] Home run bareback.
Nick Urban Dict. [Internet] home run to go all the way with. Last night I scored a home run with Lisa.
[US]L. Pettiway Honey, Honey, Miss Thang 93: I just automatically come. Yeah, just the way he’s hitting. Simple as that. Home runs.
[US]C. Fothergill-Brown ‘WWE Confidential Report’ 30 Jun. [Internet] You see you stand now before The Rock, looking at The Rock, gawking at The Rock, wanting to go one on one with The Great One. [Going ‘1 on 1’ with the Great One = Home Run.] And now in front of all The Rock’s fans you want to serve The Rock a great big piece of that ‘poontang pie?’.

In phrases

hit a home run (v.) (also score a home run, get run)

(US campus) to have sexual intercourse.

[US]Cheers [NBC-TV] First base nothing. I bet I could hit a home run with her [HDAS].
[US]Lerner et al. Dict. of Today’s Words 77: Getting run – having sex.
[US]Eble Sl. and Sociability 71: ‘To have sex’ is to score or hit a home run.