Green’s Dictionary of Slang

strep n.

[abbr.]

1. streptococcus, a form of bacterium; esp. in combs. strep throat, strep infection.

1925
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2019
[US]S. Lewis Arrowsmith 259: Can’t we just treat the fellow that has the strep infection.
[US]W. Winchell On Broadway 24 Oct. [synd. col.] Hank Greenberg [...] is at his Bronx home, with 104 temp., plus two nurses. Strep.
[US]J.M. Cain Mildred Pierce (1985) 414: All of those symptoms could have been caused by strep.
[UK]K. Fearing Big Clock (2002) 125: You’ve got a strep throat.
[US]Kerouac letter Aug. in Charters II (1999) 59: Turns out I had something like strep infection.
[US]Paducah Sun (KY) 1 Jan. 36/2: Strep throat affects up to 5 million each year [...] About 30 to 40 percent will test positive on a throat culture for strep.
Anniston Star (AL) 27 Dec. 28/3: Most of the time, strep will give ou a sore throat, headache, stomachache and feveer.
[US]Press & Sun-Bulletin (Binghampton, NY) 3 Apr. A5/4: Strep and Staph infections? Vinegar is a powerful antiseptic.

2. streptomycin, an antibiotic orig. used to combat tuberculosis, but now usu. used in combination with other drugs because of its toxicity.

1959
19591960
1961
J. Braine Vodi 85: They’d tried strep. and P.A.S.
[UK]C. Cockburn View from West 6: Hallucinated myself by the effects of streptomycin – we soon all got very matey with this potent drug and called it strep .