Green’s Dictionary of Slang

skull and crossbones n.

[the acknowledged sign for ‘poison’]

1. (US) blackmail; also attrib.

[US]W.N. Burns One-Way Ride 6: Vincenzo Cosmano [...] tried the effect of a skull-and-crossbones missive on Colosimo and was riddled with buckshot.

2. (US black) poison.

[US]R. Klein Jailhouse Jargon and Street Sl. [unpub. ms.].

3. (US black) in fig. use of sense 2, a disruptive person.

[US]R. Klein Jailhouse Jargon and Street Sl. [unpub. ms.].