Green’s Dictionary of Slang

(US) experienced at living in the West.

1855		‘California Bloomer’ in Lingenfelter et al. Songs of the Amer. West (1968) 103: I saw Miss Ella on the Platte / Where she got alkalied.
1907		S.E. White Arizona Nights 108: The trouble with you fellows [...] is that you are so plumb alkalied you don’t know the real thing when you see it.
1914		A.P. Man Jr ‘Further Word-List – Arizona’ in DN IV:ii 164: alkalied, to be, v. To be an Old Timer of the desert.
1936		R.F. Adams Cowboy Lingo 27: A man old in the ways of the West [...] was said to be ‘bone-seasoned’ or ‘alkalied,’ the latter term meaning he was acclimated to the country.