Green’s Dictionary of Slang

ball-buster n.

[balls n. (1) + SE buster; but note Yid. baleboosteh, a bossy woman, lit. ‘mistress of the house’]

1. [20C+] (US Und.) a thief who grabs his victim by the testicles while his accomplice takes his wallet.

2. [1940s+] (orig. US, also balls buster) a nagging woman.

3. [1950s–60s] (US campus) a notably hard course or examination.

4. [1950s+] any overbearingly unpleasant person or circumstances.

5. [1960s+] any thing or person seen as extraordinary or outstanding.

6. [1980s+] (also buster) a tease.