Green’s Dictionary of Slang

a blow to the nose; thus fig. a heavy blow (see cite 1889).

1848		Bell’s Life in Sydney 18 Mar. 1/4: Solid [...] planted a terrific nose-ender with his right.
1855		(con. 1852) Fights for the Championship 250: He reached Orme’s smeller, a heavy nosender which tapped his best October.
1853		N.Y. Clipper 20 Aug. 1/5: A nose-ender that drew the claret.
1867		Sportsman 1 Oct. 2/1: Notes on News [...] [F]or a sporting writer here to receive genuine ‘nose-ender’ from an excited pugilist is not unknown.
1879		Bell’s Life in London 7 June 5: Donnelly delivering a heavy nosender.
1882		Sydney Sl. Dict. (2 edn) 6: Nose-ender - A straight blow delivered full on the nasal promontory, or point. See the point?
1889		H. Smart Long Odds III 164: ‘Sim Napper, what a thundering ass you've made of yourself! [...] I shall get the sack, and Uncle Noel a real nose-ender’.
2024		J. Meades Empty Wigs (t/s) 153: Give his big hooter a bit of a bloodying, a nosender.