Green’s Dictionary of Slang

1. (US) angry.

1963

A.S. Fleischman Venetian Blonde (2006) 148: I realized I had hurt my hand. I was too smoked up at first to pay any attention.

2. (US drugs) intoxicated with cannabis.

1977		L. Heinemann Close Quarters (1987) 258: He and I would get smoked up on the morning outbound run, and get laid noontimes.
1984		Totally True Diaries of an Eighties Roller Queen 🌐 6 Aug. I went to the beach with Karey L. We got smoked up. Holy shit – were we ever stoned out of our faces.
1998		(con. 1986) G. Pelecanos Sweet Forever 36: Kids played Frisbee and caught sun [...] and get smoked up together before his class.

3. (US drugs) intoxicated with crack cocaine.

1993		E. Richards Cocaine True 14: When I get mad and smoked up I forget who I am sometimes.
2001		J. Stahl Plainclothes Naked (2002) 217: We go in there and do her, I wanna be smoked up.