Green’s Dictionary of Slang

bowels n.

SE in slang uses

In phrases

don’t get your bowels in an uproar (also don’t get your balls in an uproar)

do not make so much (unnecessary) fuss.

1948		H. McCoy Kiss Tomorrow Goodbye in Four Novels (1983) 153: ‘I shall heal no more bodies. I shall heal only minds . . .’ ‘Stop getting your bowels in such an uproar,’ Jinx said.
1967		(con. 1950s) McAleer & Dickson Unit Pride (1981) 328: Don’t get your balls in an uproar. I don’t give a good shit if you never leave.
1978		A. Maupin Tales of the City (1984) 65: I’m leaving. Don’t get your bowels in an uproar.
1990		www.holysmoke.org 18 Oct. 🌐 Now before y’all get your bowels in an uproar let me state up front that for over ten years I myself was addicted to Jesus.
1994		R. Crumb Zap Comix 13 in Coffee Table Art Book (1997) 25: Yeah yeah Don’t get yer bowels in an uproar, Sarge!
2005		billmon.org 6 Oct. 🌐 Well some of the wing nuts have their bowels in an uproar again over the Miers nomination.