1. [late 18C+] criminal or associated with the underworld; thus game woman, a prostitute; game publican, a publican who affects not to notice the breaking of the law.
2. [1930s–50s] (also gamey) of women, promiscuous.
3. [early 19C] of an animal, cantankerous.
4. [early 19C–1920s] of men, cunning, villainous.
5. [1990s+] (US campus) attractive, seductive.
[18C] a young prostitute; a promiscuous young woman.