Green’s Dictionary of Slang

(US campus) excuse me.

1977		Eble Campus Sl. Fall 5: screws me – a humorous form of ‘excuse me’.
1996		Eble Sl. and Sociability 39: Manipulating sounds for fun is consistent with the flippant, venturesome spirit of much slang use. Hence the polite apology Excuse me is playfully pronounced Screws me, Squeeze me, or Exsqueeze me.