Green’s Dictionary of Slang

piled (for French velvet) phr.

[French adj. (1)]

suffering from a venereal disease.

[UK]Shakespeare Measure for Measure I ii: I had as lief be a list of an English kersey as be piled, as thou art piled, for a French velvet.
[UK]Jonson Bartholomew Fair II v: I’ll see ’em poxed first, and piled, and double piled.