Green’s Dictionary of Slang

up adv.

1. [late 18C] drunk.

2. [late 19C+] (orig. UK Und.) arrested; in prison.

3. [1940s+] (orig. US) mentally stimulated, excited, hopeful (cf. up adj. (2)).

4. [1940s+] (also up on) intoxicated by a drug (cf. up adj. (1)).

5. [1950s+] (US black) of a person, ready, prepared.

6. [1960s+] (US campus) sexually aroused.

7. [mid-19C; 1970s] (US) upset; bothered.

8. [1980s] mentally stimulated in a positive or negative way, energised or stressed.

9. [1990s+] (US black) tense, nervous.

10. interested, participating.

11. see up to adv.

In phrases

have (someone) up (v.)

[20C+] to bring someone before the courts.

up above

[1910s] (Aus.) in prison.

up on (adv.)

see sense 4 above.

SE in slang uses

In phrases

up on it (adj.) [SE up on, adept, knowledgeable]

[1980s+] (US black) aware, knowledgeable.

up on the stickers (adj.)

[1940s] (US black) aware, appreciative of what is important.