Green’s Dictionary of Slang

(US) something or someone unimaginably bad.

1930		D.M. Garrison ‘Song of the Pipeline’ in Botkin Folk-Say 106: I’m a dirty bull-bitch, if I ain’t seen one go in there.
1939		J. Steinbeck Grapes of Wrath (1951) 50: This here’s jackrabbit. Tougher’n a bull-bitch.
1954		J. Steinbeck Sweet Thursday (1955) 165: You’re a bull-bitch idear [sic] dame.
1961		J. Steinbeck Winter of our Discontent (1963) 209: I’d even coffee you but Stoney’s mean as a bull bitch.
1970		E. Thompson A Garden of Sand (1981) 261: ‘Lousy bullbitch!’ his mother muttered.