Green’s Dictionary of Slang

cuff v.2

[NB OED 2 edn offers two cits. for cuff = to handcuff: 1693, 1851, but neither are listed as sl. and the term is ‘rare’]

1. [late 19C+] to handcuff; also as phr. put the cuff on.

2. (US campus) to initiate a relationship.

In derivatives

cuffed (adj.)

[2010s] (US campus) in a relationship.