Green’s Dictionary of Slang

1. confused.

1848		‘A Fraternal Appeal’ [campaign song] in AS (1941) XVI:1 79/2: You’ll never find on any trip That he’ll be pix-e-lated.
1886		E.L. Bynner Agnes Surriage 56: We’ll be pixilated ’n’ driven on to th’ rocks an ye don’t wake up [DA].
1891		Journal of Amer. Folklore IV 159: Words from the dialect of Marblehead. [...] Pixielated. Confused, bewildered [DA].
1895		DN I 392: Pixilated, dazed, bewildered in the dark. Marblehead, Mass.
1936		Coshocton (OH) Trib. 18 May 6/1: In a slang way out in Ohio pixillation meant a bit balmy. Silly Tom was pixillated and so was Ida Strump, who [...] came to town in her bare feet.
c.1943		‘Bill O. Lading’ You Chirped a Chinful!! n.p.: Loco: Pixilated.
1949		Chicago Trib. 22 Oct. 10/3: Our American variant ‘pixilated,’ with the generalized meaning of eccentric, confused, crazy or intoxicated, has long been familiar in Essex county, Mass [DA].
1999		T. Dorsey Florida Roadkill 153: Veale was pixilated.

2. drunk.

1949		Chicago Trib. 22 Oct. 10/3: Our American variant ‘pixilated,’ with the generalized meaning of eccentric, confused, crazy or intoxicated, has long been familiar in Essex county, Mass [DA].
1987		J. Ciardi Good Words 1225: Pixilated [...] befoodled by the alcofluence of incohol.