Green’s Dictionary of Slang

1. to overcome, to ‘use up’.

1830		N.-Y. Eve. Post 18 May 2/2: The Augusta Courier contains a specimen of a ‘Cracker Dictionary,’ which makes us acquainted with some very curious terms in use among the Southern Cockneys. [...] ‘Ramsquaddled,’ for instance, is said to mean ‘Rowed up salt river’.
1834		‘Jack Downing’ Andrew Jackson 38: [heading] All the men the Gineral ramsquaddled getted to be his friends.

2. to drink heavily, thus as adj., drunk.

1838

D. Crockett in Meine Crockett Almanacks (1955) 125: He had been ramsquaddled with whiskey for a fortnight.