Green’s Dictionary of Slang

venereal disease, esp. gonorrhoea.

c.1758		J. F---g Epistle of a Reformed Rake 17: [addressing a pimp] What’s become of Bet Legg and Nancy Welch? – Oh, Sir, they’re making Interest [...] for the Lock – very bad indeed – far gone – if they don’t succeed, they’ll turn into Drury, and so make sure of the Reformatory – they’ve been off my list these six Weeks.
1785, 1788, 1796		Grose Classical Dict. of the Vulgar Tongue.
1811		Lex. Balatronicum.
1823		Egan Grose’s Classical Dict. of the Vulgar Tongue.