Green’s Dictionary of Slang

1. (drugs) to inject a drug with a hypodermic syringe.

1933		Ersine Und. and Prison Sl.
1959		J.E. Schmidt Narcotics Lingo and Lore.
1967		‘Whisper All Aussie Dict.’ in Kings Cross Whisper (Sydney) xxxix 4/5: spike: [...] To take an injection of drugs.
1976		R. Sabbag Snowblind (1978) 237: If you are spiking anything called heroin, your days are numbered.
1989		Courtwright & Des Jarlais Addicts Who Survived 235: I never did skin pop, or never did spike – shoot it into my vein.
1996		P. Howard The Joy (2015) [ebook] I spike a vein in my right arm, draw some red, and then ram the stuff into me.
1997		Simon & Burns Corner (1998) 5: Dennis, who’s got a hospital cane all his own since he spiked himself in the neck and caught some spine.
2001		ONDCP Street Terms 20: Spike — [...] to inject a drug; needle; hypodermic needle.
2005		A. Lovejoy Acid Alex 201: Drug taught me how to spike. And I fucking loved it.

2. (also spike up) to inject someone else with a drug.

2012		C. Stella Rough Riders 132: He’s the one who spiked Nathan first [...] Roger spiked Nathan then John did it [Ibid.] 133: Did Nathan Barron want to spike up?
2013		D. Whish-Wilson Zero at the Bone [ebook] The sex was good, but most of all he loved to spike a naked girl, himself naked, watch the pleasure come into her eyes.