Green’s Dictionary of Slang

1. upset.

1899		J. Flynt Tramping with Tramps 353: W’y, what’s wrong, Cig? You look spiked. [Ibid.] 397: spiked: upset, chagrined, disappointed, disgusted.
1917		‘Banjo’ Paterson ‘Three Elephant Power’ in Three Elephant Power 3: He used to get that spiked when a car passed him, he’d nearly go mad.
1921		P. & T. Casey Gay-cat 304: Spiked—chagrined, disappointed.

2. of an ostensibly non-alcoholic drink, having had alcohol added to it; also occas. having been adulterated with a drug (see cit. 1968, 2016) [spike v.² (1)].

1933		Ersine Und. and Prison Sl.
1938		M. Rand ‘Clip-Joint Chisellers’ in Ten Story Gang Aug. 🌐 The victim was plied with spiked and loaded drinks at his or her own expense.
1959		E. De Roo Go, Man, Go! 44: They were in the back seat of Gil’s Merc tearing up the old highway to a roadside joint for spiked cokes and chips. Gil had the mixings in the bottle in his pocket.
1968		L. Wolf Voices from the Love Generation 9: I got turned on to spiked Coke, which had acid in it.
1974		G.F. Newman You Flash Bastard 92: She fetched him milk, and a tissue. ‘Want it spiked with scotch?’.
1987		‘Joe Bob Briggs’ Joe Bob Goes to the Drive-In 178: Sybil Danning is the evil queen, but she can’t get the Hulk to drink the spiked wine.
2001		C. Stella Eddie’s World 83: He saw the short man with a pint-sized orange-juice container in his right hand. ‘That spiked or you on the wagon?’.
2016		Times 20 Aug. 34/3: The decision to develop the market for pre-rolled joints, cannabis cookies, spiked soft drinks.

3. of a drink or food or occas. drug, having been adulterated with a knockout drug.

1963		T. Southern ‘Twirling at Ole Miss’ in Southern (1973) 84: Sometimes [...] mama-san would sell you spiked grass. You smoke a joint and nod right out. Probably, it was heavily opiated.
2000		P. Beatty Tuff 243: Fariq tossed Whitey a spiked Thirstbuster.