Green’s Dictionary of Slang

(US) crazy, foolish.

1928		J.P. McEvoy Showgirl 47: ‘You’d be plumb nerts’ says he, ‘to think of it.’.
1932		Quad-City Times (Davenport, IA) 6 Apr. 2/1: ‘Don’t every think I’m nerts or I’ll go sunk’.
1937		Raeburn van Buren ‘Abbie an’ Slats’ [comic strip] It’s so quiet it’ll drive me nertz.
1944		H.B. Hersey G.I. Laughs 118: [cartoon] I thought my charley-horse would drive me nertz!
1972		(con. 1916) G. Swarthout Tin Lizzie Troop (1978) 125: If I don’t have a bath pretty soon [...] I’ll go absolutely nertz.