1. [mid-17C; 19C+] (also rat poison) an ironic term for drink in general.
2. in senses of someone or something harmful.
(a) [mid-19C+] an unpleasant person, best to be avoided; also used semi-affectionately.
(b) [1920s–30s] something that one should avoid, i.e. something suspicious.
(c) [1930s–50s] (US drugs) a doctor who refuses to prescribe narcotics.
3. in drug uses.
(a) [1920s] cocaine.
(b) [1950s+] (drugs) heroin, esp. in its pure state.
(c) [1980s] (S.Afr.) marijuana.
(d) [2000s] fentanyl.
[1900s] (Aus.) a public house.
[1900s] (US) a bar counter.
[1960s–70s] (US black) heroin addicts, taken as a group.
1. [late 19C+] a (down-market) public house, orig. used by temperance reformers.
2. [1950s] a brothel.
[late 19C] (US) a barman.
[mid-19C+] (orig. US) an invitation to a fellow drinker to make a choice of drink at a party or in a bar (cf. give it a name under name n.).
[1920s] to slander, to malign a person’s character, esp. in court.
see separate entry.
SE in slang uses
[1930s–40s] (US Und.) a pharmacy; a drug store.
[late 17C–early 19C] a redhead; thus poison-pated adj., red-haired.