Green’s Dictionary of Slang

frazzled adj.

[East Anglia dial. frazzle, to wear away, to unravel; ult. SE fray]

1. [19C+] (orig. US, also frazzle-assed, frazzled out) emotionally drained, physically exhausted.

2. [19C+] (orig. US) drunk.

3. [1970s+] (US drugs) under the influence of a drug, e.g. cocaine or marijuana.