Green’s Dictionary of Slang

1. (Aus.) to rob.

1941

Baker Popular Dict. Aus. Sl.

2. (US) to whip.

1905

J.W. Carr ‘Words from Northwest Arkansas’ in DN III:i 80: frazzle, v. To whip severely.

3. (US) to excite, to render upset.

1950		S.J. Perelman letter 2 Aug. in Crowther Don’t Tread on Me (1987) 104: The two little charges can occupy themselves [...] in the surf instead of frazzling their parents’ nerves.
1964		J. Thompson Pop. 1280 in Four Novels (1983) 390: He frazzled me [...] Got me so God-danged excited.
1976		Woodward & Bernstein Final Days 209: The wiretapping accusations had frazzled him.

4. (US drugs) to wear out throw drug use.

2000

Indep. Rev. 11 Feb. 10: The experience of it [i.e. marijuana] has so frazzled his brain.

5. to defeat, to overcome.

2006

D. Mitchell Black Swan Green 125: Mrs Thatcher frazzled this twerpy prat in a bow tie on BBC1.