Green’s Dictionary of Slang

1. ruined, given up, abandoned.

1864, 1867, 1870		Hotten Sl. Dict.
1873		Sl. Dict.
1895		C. Crowe Aus. Sl. Dict. 39: Jacked Up (or chucked up), suddenly leaving off doing work.

2. (US) pregnant.

1999

D. Lypchuk ‘A dirty little story’ in eye mag. 8 July 🌐 Thank God he wore a glove or she could be jacked up with a permanent slimming cool, creepers or the dreaded coachman on the box.

3. (US) worn-out; injured.

2012

M. Lacher On the Bro’d 183: He grabbd his jacked-up duffel [bag] full of energy gel [ibid.] 183: It was like Derek’s jacked-up thumb was totallyt what he was about.